Cellular and molecular mechanisms underlying behaviour and learning in mammals

哺乳动物行为和学习的细胞和分子机制

• 批准号: 355371-2008
• 负责人: Schmid, Susanne
• 金额: $ 1.6万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497155
• 关键词: Cellular; molecular; mechanisms; underlying; behaviour

It is one of the major challenges for modern Neuroscience to find out how behaviour is generated and modulated in the mammalian brain. Mammalian brains are complex structures mediating complex behavioural tasks. In order to be able to connect cellular and molecular processes within the brain to a specific behavioural task we use a well established simple model - the startle response. Startle responses are mediated by a short primary pathway, they can easily be quantified and they are modulated by sensory gating mechanisms, emotions and different learning processes. This turns startle into a perfect model for studying underlying cellular and molecular mechanisms.

找出哺乳动物大脑中行为是如何产生和调节的，是现代神经科学面临的主要挑战之一。哺乳动物的大脑是调节复杂行为任务的复杂结构。为了能够将大脑内的细胞和分子过程与特定的行为任务联系起来，我们使用了一个完善的简单模型——惊吓反应。惊吓反应是由一个短的主要通路介导的，它们很容易被量化，并且受到感觉门控机制、情绪和不同学习过程的调节。这将惊吓变成了研究潜在细胞和分子机制的完美模型。