Synthetic chemistry based on Rh(II)-carbenoid reactions and synthesis of alkaloids

基于Rh(II)-类胡萝卜素反应的合成化学和生物碱的合成

• 批准号: 37411-2008
• 负责人: Wee, AndrewGH
• 金额: $ 2.04万
• 依托单位: University of Regina
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497829
• 关键词: Synthetic; chemistry; based; Rh; II

There is an increasing demand for organic molecules with diverse structural features and functionality for use in the manufacturing of new materials, in the discovery of new medicines and in the chemical industry for the manufacture of fine chemicals. Novel bioactive molecules are also useful as "tools" for studying and understanding biochemical processes, which would have important implications in the advancement of medical research. Some of the molecules are not made by nature and others that occur in nature are only available in small amounts. Extracting such compounds from nature can have negative impacts on our environment and the ecosystem. Organic synthesis provides a way for making these molecules available and in sufficient quantities so that studies on their (bio)chemical and physical properties can be conducted. The proposed research is concerned with the design, study and development of new methods and catalysts for making of new compounds from simple organic building blocks. The ultimate goal in these studies is to develop practical methods that can be used for the synthesis of medicinally important, biologically active compounds. New drugs, such as anticancer, antihypertensive and anti-inflammatory drugs, can benefit health of society. The results from the proposed studies will contribute to the knowledge base in the chemical sciences and to the advancement in chemical synthesis. The latter plays a vital role in the chemical and pharmaceutical manufacturing sectors in Canada and hence the economy of Canada. Another important aspect of my research program is the training of graduates and undergraduates in the methodology of scientific inquiry and research, which helps ensure that Canada has the technological edge to compete in the global economy.

人们对具有不同结构特征和功能的有机分子的需求越来越大，用于制造新材料、发现新药物和在化学工业中制造精细化学品。新的生物活性分子也是研究和理解生化过程的有用工具，这将对医学研究的发展具有重要意义。其中一些分子不是自然界制造的，而另一些自然界中存在的分子只有少量可用。从大自然中提取这种化合物可能会对我们的环境和生态系统产生负面影响。有机合成提供了一种方法，使这些分子可以获得和足够的数量，以便研究它们的(生物)化学和物理性质。拟议的研究涉及设计、研究和开发从简单的有机构件制备新化合物的新方法和催化剂。这些研究的最终目标是开发实用的方法，用于合成具有重要医学价值和生物活性的化合物。新药，如抗癌、降压和抗炎药物，可以造福社会健康。拟议研究的结果将有助于化学科学的知识库和化学合成的进步。后者在加拿大的化学和制药制造部门发挥着至关重要的作用，因此对加拿大的经济也是如此。我的研究计划的另一个重要方面是对毕业生和本科生进行科学探究和研究方法的培训，这有助于确保加拿大拥有在全球经济中竞争的技术优势。