Apoptosis regulation by RNA binding proteins

RNA 结合蛋白的细胞凋亡调节

• 批准号: 261206-2009
• 负责人: Sutherland, Leslie
• 金额: $ 2.33万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498081
• 关键词: Apoptosis; regulation; RNA; binding; proteins

All cells have the ability to self-destruct, a process called apoptosis. Apoptosis is controlled by various cellular factors, termed proteins, that are produced when needed - for instance when cells are starved of the nutrients upon which they depend for survival. These apoptosis-related proteins work in many different ways to shrink the cell, break it into pieces and ensure that the remnants are recycled by neighbouring, healthy cells. How the apoptosis-related proteins are triggered to carry out these tasks is an active area of research within the scientific community, and although many mechanisms have been identified, new ones are regularly emerging. We are interested in investigating how one potential apoptosis-controlling protein, RBM10, works. We propose that RBM10 is capable of boosting apoptosis and that it does this by changing the structure of various cellular factors, thereby changing their function. We plan to examine if and how RBM10 controls apoptosis, in the hopes of better understanding how cells, in general, regulate this very important process. Since the control of cell death is fundamental to many - if not all - other processes within living organisms, the results of the proposed work have the potential to impact on a wide range of research areas.

所有细胞都有自我毁灭的能力，这一过程称为凋亡。细胞凋亡是由各种细胞因子控制的，这些细胞因子被称为蛋白质，它们在需要时产生-例如当细胞缺乏它们赖以生存的营养时。这些凋亡相关的蛋白质以许多不同的方式工作，使细胞缩小，将其破碎成碎片，并确保残余物被邻近的健康细胞回收。如何触发阿尔茨海默病相关蛋白质执行这些任务是科学界研究的一个活跃领域，尽管已经确定了许多机制，但新的机制经常出现。我们感兴趣的是研究一种潜在的糖尿病控制蛋白RBM 10是如何工作的。我们认为RBM 10能够促进细胞凋亡，并且它通过改变各种细胞因子的结构来实现这一点，从而改变它们的功能。我们计划研究RBM 10是否以及如何控制细胞凋亡，希望更好地了解细胞如何调节这一非常重要的过程。由于细胞死亡的控制是生物体内许多（如果不是所有）其他过程的基础，因此拟议工作的结果有可能影响广泛的研究领域。