Apoptosis regulation by RNA binding proteins

RNA 结合蛋白的细胞凋亡调节

• 批准号: 261206-2009
• 负责人: Sutherland, Leslie
• 金额: $ 2.33万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525130
• 关键词: Apoptosis; regulation; RNA; binding; proteins

All cells have the ability to self-destruct, a process called apoptosis. Apoptosis is controlled by various cellular factors, termed proteins, that are produced when needed - for instance when cells are starved of the nutrients upon which they depend for survival. These apoptosis-related proteins work in many different ways to shrink the cell, break it into pieces and ensure that the remnants are recycled by neighbouring, healthy cells. How the apoptosis-related proteins are triggered to carry out these tasks is an active area of research within the scientific community, and although many mechanisms have been identified, new ones are regularly emerging. We are interested in investigating how one potential apoptosis-controlling protein, RBM10, works. We propose that RBM10 is capable of boosting apoptosis and that it does this by changing the structure of various cellular factors, thereby changing their function. We plan to examine if and how RBM10 controls apoptosis, in the hopes of better understanding how cells, in general, regulate this very important process. Since the control of cell death is fundamental to many - if not all - other processes within living organisms, the results of the proposed work have the potential to impact on a wide range of research areas.

所有的细胞都有自我毁灭的能力，这一过程称为细胞凋亡。细胞凋亡是由各种细胞因子控制的，称为蛋白质，在需要时产生--例如当细胞缺乏赖以生存的营养物质时。这些与细胞凋亡相关的蛋白质以多种不同的方式发挥作用，缩小细胞，将其分解成碎片，并确保残留物被邻近的健康细胞回收利用。如何触发凋亡相关蛋白执行这些任务是科学界一个活跃的研究领域，尽管已经发现了许多机制，但新的机制不断涌现。我们有兴趣研究一种潜在的凋亡控制蛋白RBM10是如何发挥作用的。我们认为RBM10能够促进细胞凋亡，它是通过改变各种细胞因子的结构从而改变它们的功能来实现这一点的。我们计划研究RBM10是否以及如何控制细胞凋亡，希望更好地了解细胞一般是如何调控这一非常重要的过程的。由于细胞死亡的控制对生物体内的许多其他过程是基本的--如果不是全部的话，拟议工作的结果可能会对广泛的研究领域产生影响。