Revealing secrets of cellular phosphorylation systems using mass spectrometry

使用质谱揭示细胞磷酸化系统的秘密

• 批准号: 298468-2009
• 负责人: Vacratsis, Panayiotis
• 金额: $ 2.7万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498140
• 关键词: Revealing; secrets; cellular; phosphorylation; systems

Reversible phosphorylation is a protein modification utilized as a "light switch" to turn the activity of enzymes on and off. Proper execution of this process is vital for a vast array of biological events including cellular growth, development, metabolism, and survival. The kinase and phosphatase enzymes that put on and take off this chemical group must be under tight control in order to achieve cellular organization and avoid promotion of disease states. Therefore, a major theme of our research program is to learn more about poorly understood kinases and phosphatases predicted to function in critical cellular processes such as cellular growth and survival.

可逆磷酸化是一种蛋白质修饰，被用作“电灯开关”来打开和关闭酶的活性。正确执行这一过程对包括细胞生长、发育、代谢和生存在内的大量生物事件至关重要。为了实现细胞组织和避免疾病状态的促进，必须严格控制激酶和磷酸酶的加入和取下这一化学基团。因此，我们研究计划的一个主要主题是了解更多关于在细胞生长和存活等关键细胞过程中预测功能的知之甚少的激酶和磷酸酶。