Revealing secrets of cellular phosphorylation systems using mass spectrometry

使用质谱揭示细胞磷酸化系统的秘密

• 批准号: 298468-2009
• 负责人: Vacratsis, Panayiotis
• 金额: $ 2.7万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548338
• 关键词: Revealing; secrets; cellular; phosphorylation; systems

Reversible phosphorylation is a protein modification utilized as a "light switch" to turn the activity of enzymes on and off. Proper execution of this process is vital for a vast array of biological events including cellular growth, development, metabolism, and survival. The kinase and phosphatase enzymes that put on and take off this chemical group must be under tight control in order to achieve cellular organization and avoid promotion of disease states. Therefore, a major theme of our research program is to learn more about poorly understood kinases and phosphatases predicted to function in critical cellular processes such as cellular growth and survival.

可逆磷酸化是一种蛋白质修饰，用作“光开关”来打开和关闭酶的活性。 这个过程的正确执行对于包括细胞生长、发育、代谢和存活在内的大量生物事件至关重要。 激酶和磷酸酶，穿上和脱下这个化学基团必须在严格的控制下，以实现细胞组织和避免促进疾病状态。 因此，我们研究计划的一个主要主题是更多地了解预测在细胞生长和存活等关键细胞过程中发挥作用的鲜为人知的激酶和磷酸酶。