Regulation of nucleoside transporters

核苷转运蛋白的调节

• 批准号: 298548-2009
• 负责人: Hammond, James
• 金额: $ 2.7万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498142
• 关键词: Regulation; nucleoside; transporters

Cells contain proteins in their membranes that enable the transfer of important nutrients into the cell, as well as the removal of unwanted substances from the cells. We are studying one particular type of these "transport" proteins that is involved in the cellular uptake and release of nucleosides. Nucleosides are a class of substances that are used as the building blocks for DNA and RNA, and are also important for controlling many other aspects of cell function. Cells require different levels of nucleosides at different times, and must adapt to their environment to ensure that the nucleoside concentrations, both inside and outside the cell, are maintained at specific levels. We are studying this cellular adaptation process. Our studies are focussed on how cells regulate the number and activity of "nucleoside transporters". An increase or decrease in nucleoside transporter activity has been known to modify blood flow to tissues, protect the heart and brain tissue from damage during transient ischemic episodes, and modify the duration of seizures. A better understanding of how the body regulates these transporters will enhance our ability to develop better therapies for conditions such as heart failure, seizures, and stroke. These studies will also enhance our understanding of how the cell regulates its metabolism in response to environmental influences.

细胞的膜中含有蛋白质，能够将重要的营养物质转移到细胞内，并从细胞中清除不需要的物质。我们正在研究一种特殊类型的这种“运输”蛋白，它与细胞对核苷的摄取和释放有关。核苷是一类用作构建DNA和RNA的物质，对控制细胞功能的许多其他方面也很重要。细胞在不同的时间需要不同水平的核苷，必须适应其环境，以确保细胞内外的核苷浓度保持在特定的水平。我们正在研究这种细胞适应过程。我们的研究集中在细胞如何调节“核苷转运体”的数量和活性。核苷转运体活性的增加或减少已被认为可以改变流向组织的血液，保护心脏和脑组织免受短暂性脑缺血发作的损害，并改变癫痫发作的持续时间。更好地了解身体是如何调节这些转运蛋白的，将增强我们开发更好的治疗心力衰竭、癫痫和中风等疾病的能力。这些研究还将加强我们对细胞如何调节其新陈代谢以应对环境影响的理解。