Understanding and Innovation in Dairy for the Management of Body Weight and Metabolic Disease

在加拿大，大约60%的成年人和30%的儿童超重或肥胖，15%的人患有代谢综合征，包括高血糖、高血压和胆固醇。在过去的25年里，我国人口中肥胖和超重的患病率翻了一番，而人均牛奶消费量下降了20%。大多数加拿大人并不像加拿大《食物指南》所推荐的那样每天食用两到三份食物。近年来，许多人群研究表明，较高的乳制品摄入量与较健康的体重和降低患高血糖、高血压和胆固醇的风险有关。我们研究的总体目标是解释后一种联系。我们的目标是描述传统的和创新的牛奶和乳制品，单独或与食物一起食用，对健康体重、超重和肥胖的成年人和儿童的食物摄入量、血糖、血压和胆固醇的影响及其调节。这项提案描述了几个实现这一目标的实验。我们预计，这一结果将使人们对牛奶的健康益处和提供这些益处的作用机制有一个新的理解。通过提供科学可靠的证据来传播牛奶的健康益处，而不仅仅是提供营养的传统角色，预计牛奶的消费量将会增加。此外，通过了解牛奶及其成分对调节食物摄取和新陈代谢的生理系统的影响，我们可以鼓励新产品的开发，以提高益处。结果不仅对消费者和降低医疗成本有潜在的好处，而且对从生产者到消费者的完整价值链也有潜在的好处

Approximately 60% of adults and 30% of children in Canada are overweight or obese and 15% suffer from the metabolic syndrome, which includes high blood sugar, blood pressure, and cholesterol. The prevalence of obesity and overweight in our population has doubled over the past 25 years, while per capita milk consumption has decreased by 20%. A majority of Canadians do not consume the recommended two to three servings per day, as recommended by Canada's Food Guide. In recent years many population studies have associated higher dairy consumption with healthier body weights and reduced risk of developing high blood sugar, blood pressure and cholesterol. The overall goal of our research is to explain the latter association. We aim to describe the effects of traditional and innovative milk and dairy products, consumed alone or with meals, on food intake, blood sugar, blood pressure and cholesterol and their regulation in healthy body weight, overweight and obese adults and children. Several experiments toward that goal are described in this proposal. We anticipate that the results will lead to a new understanding of the health benefits and the mechanisms of action of milk in providing these benefits. By providing scientifically sound evidence for communicating health benefits of milk beyond its traditional role of providing nutrients, it is expected that consumption will increase. In addition, by understanding the effect of milk and its components on physiologic systems regulating food intake and metabolism, we can encourage the development of new products that enhance the benefits. The results have potential benefits to not only the consumer and the reduction of health care cost, but also to the complete value chain from producer to consumer