Food proteins and peptides in the regulation of metabolic homeostasis and food intake in rats

食物蛋白质和肽在大鼠代谢稳态和食物摄入调节中的作用

• 批准号: 18-2011
• 负责人: Anderson, GeraldHarvey
• 金额: $ 2.91万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=568088
• 关键词: Food; proteins; peptides; regulation; metabolic

Obesity is becoming the most costly public health problem with the number of deaths due to its associated metabolic diseases approaching the number of deaths attributed to smoking. Obesity and its associated diseases consume approximately 5% of the health care budget in Canada. In the US the estimate is close to 10%. Clearly there is an urgency to understand the role of food and food components in the regulation of food intake. My long-term interest has been in the elucidation of the mechanisms by which food proteins suppress hunger and provide feelings of satiety. Experiments in both experimental animals and humans have shown that protein is more satiating than fats or carbohydrates. In recent years the popularity of the high protein diets suggests that many people find this to be true for weight-loss diets. The mechanisms by which proteins bring about satiety are unknown, and the elucidation of these is the focus of my research. Specifically I want to determine how food proteins and the peptides released during digestion provide satiety signals from the gastrointestinal tract to the brain. The practical goal of this research is to use our understanding of mechanisms to formulate food products (functional foods and nutraceuticals) that will assist individuals to reduce calorie intact and to maintain healthy body weights. In addition we will be able to give better advice on the selection of foods that enhance satiety and we may be able to develop drugs that stimulate the brain satiety mechanisms indirectly via the gut, rather than use drugs that directly impact on the brain and thus have many untoward side effects.

肥胖症正在成为代价最高的公共卫生问题，其相关代谢疾病导致的死亡人数接近吸烟导致的死亡人数。 肥胖及其相关疾病消耗了加拿大约5%的卫生保健预算。 在美国，这一估计接近10%。 显然，迫切需要了解食物和食物成分在调节食物摄入中的作用。 我的长期兴趣一直是阐明食物蛋白质抑制饥饿和提供饱腹感的机制。在实验动物和人类身上的实验都表明，蛋白质比脂肪或碳水化合物更有饱腹感。近年来，高蛋白饮食的流行表明，许多人发现这对减肥饮食是正确的。 蛋白质带来饱腹感的机制尚不清楚，对这些机制的阐明是我研究的重点。 具体来说，我想确定食物蛋白质和消化过程中释放的肽如何从胃肠道向大脑提供饱腹感信号。 这项研究的实际目标是利用我们对机制的理解来制定食品（功能性食品和营养食品），以帮助个人减少热量并保持健康的体重。此外，我们将能够在选择增强饱腹感的食物方面提供更好的建议，我们可能能够开发通过肠道间接刺激大脑饱腹感机制的药物，而不是使用直接影响大脑的药物，从而产生许多不良副作用。