Elucidating the Role of Skeletal Muscle SIRT1/PGC-1a Metabolic Axis in Modulating Angiogenesis: Can Vascular Aging be Reversed?

阐明骨骼肌 SIRT1/PGC-1a 代谢轴在调节血管生成中的作用：血管衰老可以逆转吗？

• 批准号: 247352
• 负责人: Safdar Syed A
• 金额: $ 10.2万
• 依托单位: Beth Israel Deaconess Medical Center (Boston)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-11-01 至 2013-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=247352&lang=en
• 关键词: Adenoviral Transfection/Cell Culture; Aging; Angiogenesis; Elisa; Ischemia Disease; Pgc-1a/Sirt1 Metabolism; Quantitative Real-Time Rt-Pcr; Skeletal Muscle - Hind Limb Ischemia Model; Transgenic Mouse Models; Western Blot

Over the last 50 years, the proportion of the Canadian population over 65 y has nearly tripled, with a concomitant rise in the incidence of aging-associated ischemic diseases that continuously threatens to overwhelm our healthcare system. Investigating me

在过去的 50 年里，加拿大 65 岁以上人口的比例几乎增加了两倍，随之而来的是与衰老相关的缺血性疾病的发病率上升，这些疾病不断威胁着我们的医疗系统。调查我