Ion transport mechanisms in transporting epithelia of aquatic insect larvae

水生昆虫幼虫上皮细胞转运的离子转运机制

• 批准号: 355910-2008
• 负责人: Donini, Andrew
• 金额: $ 1.95万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=504096
• 关键词: Ion; transport; mechanisms; transporting; epithelia

My research examines how ions such as sodium, chloride and potassium are transported across cells of organs that are responsible for maintaining appropriate ion levels in the blood. This is a fundamentally important process for all living animals because blood ion levels affect the function of the nervous system, the heart, and most other organs. I am focusing on how ion transport occurs in anal papillae of mosquito and midge fly larvae, and how these processes can be regulated via the nervous system when larvae are subjected to a changing environment (from freshwater to salt-water and vice versa). This routinely happens in the natural habitats of mosquitoes through heavy rainfall and evaporation. Anal papillae are sac like organs that project out from the rear end of the animal. These anal papillae help mosquito larvae to survive under freshwater conditions by taking ions from the water and transporting them into the haemolymph (insect blood). Many mosquito species are capable of surviving in salt-water and the role of the anal papillae in these mosquitoes is not well understood. Therefore I am studying 2 closely related mosquitoes, one of which lives in freshwater and the other in salt-water. In addition, I am examining the midge fly larvae because their anal papillae receive direct inputs from the nervous system. Through these studies I will train students in physiological techniques that are applied in basic, medical and pharmaceutical research in both academic and private sector settings. My research will contribute to the understanding of ion transport mechanisms of transporting tissues and their regulation by the nervous system, fundamentally important processes for all animals. In addition my research can lead to the development of new and specific ways of controlling mosquito populations that transmit diseases such as West Nile Virus and Malaria.

我的研究探讨了离子，如钠，氯和钾是如何在负责维持血液中适当离子水平的器官细胞中运输的。这对所有活着的动物来说都是一个至关重要的过程，因为血液中的离子水平会影响神经系统、心脏和大多数其他器官的功能。我专注于离子运输如何发生在蚊子和吸浆虫幼虫的肛门乳头，以及当幼虫受到不断变化的环境（从淡水到盐水，反之亦然）时，这些过程如何通过神经系统进行调节。这通常发生在蚊子的自然栖息地，通过大量降雨和蒸发。肛门乳头是从动物的后端突出的囊状器官。这些肛门乳头帮助蚊子幼虫在淡水条件下生存，通过从水中吸收离子并将其输送到血淋巴（昆虫血液）中。许多蚊子物种能够在盐水中生存，但肛门乳头在这些蚊子中的作用还不清楚。因此，我正在研究两种密切相关的蚊子，其中一种生活在淡水中，另一种生活在盐水中。此外，我正在检查吸浆虫幼虫，因为它们的肛门乳头直接接受来自神经系统的输入。通过这些研究，我将培养学生在基础，医学和制药研究在学术和私营部门设置应用生理技术。我的研究将有助于理解运输组织的离子运输机制及其通过神经系统的调节，这对所有动物都是至关重要的过程。此外，我的研究可以导致控制传播西尼罗河病毒和疟疾等疾病的蚊子种群的新的和具体的方法的发展。