Regulation of peripheral vascular function

我们的长期研究目标是确定组织细胞如何将其需求传递给血管，以保持足够的血液流动，确保适当的组织功能。组织，例如骨骼肌，可以直接将代谢需求传递给血管系统，以便在一系列骨骼肌活动中保持适当的血流量，即休息和锻炼。这种血流控制是如何实现的还不是很清楚。我们计划将骨骼肌和显微镜的使用结合起来，这样就可以在不同水平的骨骼肌活动下直接看到血管。有了这个模型，我们将能够识别骨骼肌细胞如何向血管细胞发出信号，以传达它们的需求，以及血管细胞如何相互通信，最终改变流向工作肌肉的血液。

Our long term research goals are to determine how cells of tissues communicate their needs to blood vessels in order to maintain adequate blood flow and ensure proper tissue function. Tissues, skeletal muscle for example, can communicate metabolic needs directly to the vasculature in order to maintain appropriate blood flow over a range of skeletal muscle activities i.e rest and exercise. How this blood flow control is achieved is not well understood. We plan to combine the use of skeletal muscle and microscopy such that the blood vessels can be visualized directly under different levels of skeletal muscle activity. With this model we will be able to identify how skeletal muscle cells signal the cells of the blood vessels to communicate their needs and how cells of the blood vessels intercommunicate with each other to eventually change blood flow to the working muscles.