Regulation of peripheral vascular function

周围血管功能的调节

• 批准号: 238379-2009
• 负责人: Murrant, Coral
• 金额: $ 2.19万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=504127
• 关键词: Regulation; peripheral; vascular; function

Our long term research goals are to determine how cells of tissues communicate their needs to blood vessels in order to maintain adequate blood flow and ensure proper tissue function. Tissues, skeletal muscle for example, can communicate metabolic needs directly to the vasculature in order to maintain appropriate blood flow over a range of skeletal muscle activities i.e rest and exercise. How this blood flow control is achieved is not well understood. We plan to combine the use of skeletal muscle and microscopy such that the blood vessels can be visualized directly under different levels of skeletal muscle activity. With this model we will be able to identify how skeletal muscle cells signal the cells of the blood vessels to communicate their needs and how cells of the blood vessels intercommunicate with each other to eventually change blood flow to the working muscles.

我们的长期研究目标是确定组织细胞如何将它们的需求传达给血管，以维持足够的血液流动并确保适当的组织功能。组织，例如骨骼肌，可以将代谢需求直接传达给脉管系统，以便在一系列骨骼肌活动（如休息和锻炼）中保持适当的血液流动。这种血流控制是如何实现的尚不清楚。我们计划结合骨骼肌和显微镜的使用，这样就可以直接看到不同水平骨骼肌活动下的血管。有了这个模型，我们将能够确定骨骼肌细胞如何向血管细胞发出信号，以传达它们的需求，以及血管细胞如何相互交流，最终改变流向工作肌肉的血液。