Molecular Interactions that modulate PI3 Kinase and MAP Kinase pathways during apoptosis

当受伤时，中枢神经系统（CNS：脑和脊髓）神经元启动一个精心策划的“自杀”程序，称为细胞凋亡。控制这种自杀程序的元件在不同物种中是保守的，并且在各种各样的人类CNS疾病中观察到。研究已经导致对低等动物CNS发育过程中细胞凋亡机制的更完整的理解。然而，对成年哺乳动物中枢神经系统神经元的这一过程知之甚少。

When injured, central nervous system (CNS: brain and spinal cord) neurons initiate a carefully orchestrated "suicide" program, called apoptosis. The elements that control this suicide program are conserved throughout different species and observed in a wide variety of human diseases of the CNS. Research has lead to a more complete understanding of the mechanisms of apoptosis during development of CNS in lower animals. However, relatively little is known about this process in adult mammalian CNS neurons.