Role of annexin A2 as a scavenger of reactive oxygen species

活性氧（ROS）是在代谢过程中产生的分子，其破坏许多细胞组分，包括DNA、蛋白质和脂质。DNA包含将遗传特征从现有细胞传递到新细胞的所有遗传信息，而蛋白质是身体细胞、组织和器官的结构、功能和调节所必需的，脂质不仅是燃料的来源，而且是细胞结构的重要组成部分。对这些成分中的任何一种的损害都可能导致细胞死亡。为了保护细胞免受ROS的有害影响，细胞释放抗氧化蛋白和物质。我们实验室的初步工作表明，蛋白膜联蛋白A2（也称为ANXA 2）的耗竭导致应激细胞中ROS水平的增加。由于ANXA 2是一种非常丰富和广泛分布的细胞蛋白，我们假设ANXA 2可能在保护细胞免受氧化应激中发挥重要作用，通过吸收ROS，就像海绵吸水一样。 通过这个项目，我们将详细研究ANXA 2保护细胞免受这些有害ROS分子影响的机制。

Reactive Oxygen Species (ROS) are molecules produced during metabolism that damage a number of cellular components, including the DNA, proteins and lipids. The DNA contains all the genetic information for the transmission of inherited traits from an existing cell to a new cell, while proteins are required for the structure, function and regulation of the body's cells, tissues and organs and lipids are not only a source of fuel but also an important constituent of the structure of cells. Harm to any of these components can lead to cell death. To protect cells from the deleterious effects of ROS, cells release antioxidant proteins and substances. Preliminary work from our laboratory has shown that depletion of the protein annexin A2 (also known as ANXA2) leads to an increase in ROS levels in stressed cells. Since ANXA2 is a very abundant and widely distributed cellular protein, we hypothesized that ANXA2 might play a major role in protecting cells from oxidative stress by absorbing ROS like a sponge absorbs water. With this project we will investigate in detail the mechanisms by which ANXA2 protects the cells from these harmful ROS molecules.