Expression and function of discoidin domain receptor 1 in T cells

T细胞中盘状蛋白结构域受体1的表达和功能

• 批准号: 327042-2012
• 负责人: Aoudjit, Fawzi
• 金额: $ 2.04万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505823
• 关键词: Expression; function; discoidin; domain; receptor

The immune system is a complex system composed of several types of cells that have the function to protect the organism against infectious diseases and cancer. Among these cells are the so-called lymphocytes which are central for mounting a specific immune response. These cells patrol the organism through circulation in the blood and lymphatic systems for the presence of infectious agents or cancer cells. When this occurs, lymphocytes leave the circulation and enter the injured tissue to mount a specific immune response that aims at destroying the infected cells or the tumor cells. It is unclear how lymphocytes migrate from the circulation to enter the tissue. Our research program addresses this aspect and aims at understanding the basic mechanisms that regulate the migration of lymphocytes into the tissue. We have identified one receptor expressed by lymphocytes called discoidin domain receptor 1, which can be critical for the migration of lymphocytes. We thus propose to characterize how this receptor is expressed on lymphocytes and how it promotes their migratory function. Understanding the basic mechanisms of how lymphocytes migrate into the tissue will bring new insights in understanding the development of an immune response and will further our knowledge of how the immune system works to protect the organism. Therefore, our research will be beneficial to scientists working in the field of immunology. In addition, the proposed research will also be of interest for scientists working in cell biology and who are interested in cell migration mechanisms as this process also occurs during development and tissue regeneration.

免疫系统是一个复杂的系统，由几种类型的细胞组成，这些细胞具有保护机体免受传染病和癌症侵袭的功能。在这些细胞中有所谓的淋巴细胞，它们是建立特定免疫反应的中心。这些细胞通过血液和淋巴系统中的循环在生物体中巡逻，以寻找感染性病原体或癌细胞的存在。当这种情况发生时，淋巴细胞离开血液循环，进入受伤的组织，启动一种特定的免疫反应，旨在摧毁感染的细胞或肿瘤细胞。目前尚不清楚淋巴细胞是如何从循环中迁移到组织中的。我们的研究计划针对这一方面，旨在了解调节淋巴细胞迁移到组织中的基本机制。我们已经确定了淋巴细胞表达的一种受体，称为盘状结构域受体1，它对淋巴细胞的迁移至关重要。因此，我们建议表征这种受体是如何在淋巴细胞上表达的，以及它是如何促进其迁移功能的。了解淋巴细胞如何迁移到组织中的基本机制将为理解免疫反应的发展带来新的见解，并将进一步加深我们对免疫系统如何保护有机体的了解。因此，我们的研究将有益于免疫学领域的科学家。此外，这项拟议的研究也将引起从事细胞生物学工作的科学家的兴趣，他们对细胞迁移机制感兴趣，因为这个过程也发生在发育和组织再生过程中。