Interactions between growth and pattern formation during development

基因表达和形态之间的相互作用是复杂的，而且鲜为人知。随着植物和动物独立地进化出多细胞，找出不同王国的形态发生机制在多大程度上相似或不同将特别令人着迷。目前的数据表明，驱动生长中的鱼鳍的骨射线图案形成的机制与正在生长的植物叶片中的血管图案相似。我们将结合实验和计算方法来揭示协调网络结构(叶脉、鳍骨射线)的发展与发育中的多细胞附属物(拟南芥的叶子、丹尼欧的鳍)生长的基本机制。

Interactions between gene expression and morphology are complex and little understood. As plants and animals evolved multicellularity independently, it would be particularly fascinating to find out to what extent mechanisms of morphogenesis are similar or differ across kingdoms. Current data suggests similarities in the mechanisms driving bony ray pattern formation in growing fish fins and vascular patterns in growing plant leaves. We will combine experimental and computational approaches to uncover fundamental mechanisms that coordinate the development of network structures (leaf veins, fin bony rays) with growth in developing multicellular appendages (leaves of Arabidopsis thaliana, fins of Danio rerio).