Interactions between growth and pattern formation during development

发育过程中生长与模式形成之间的相互作用

• 批准号: 327059-2012
• 负责人: RollandLagan, AnneGaelle
• 金额: $ 2.04万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526801
• 关键词: Interactions; between; growth; pattern; formation

Interactions between gene expression and morphology are complex and little understood. As plants and animals evolved multicellularity independently, it would be particularly fascinating to find out to what extent mechanisms of morphogenesis are similar or differ across kingdoms. Current data suggests similarities in the mechanisms driving bony ray pattern formation in growing fish fins and vascular patterns in growing plant leaves. We will combine experimental and computational approaches to uncover fundamental mechanisms that coordinate the development of network structures (leaf veins, fin bony rays) with growth in developing multicellular appendages (leaves of Arabidopsis thaliana, fins of Danio rerio).

基因表达和形态之间的相互作用是复杂的，很少了解。由于植物和动物独立地进化成多细胞生物，因此找出不同界的形态发生机制在多大程度上相似或不同将是特别有趣的。目前的数据表明，驱动骨射线图案形成的机制在不断增长的鱼鳍和血管模式在不断增长的植物叶片的相似之处。我们将联合收割机实验和计算方法相结合，以揭示基本机制，协调网络结构（叶脉，鳍骨射线）的发展与发展中的多细胞附属物（拟南芥的叶子，斑马鱼的鳍）的增长。