Role of Activating Protein 1 in Skeletal Myogenesis

激活蛋白 1 在骨骼肌生成中的作用

• 批准号: 154249-2012
• 负责人: McDermott, John
• 金额: $ 2.48万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506022
• 关键词: Role; Activating; Protein; Skeletal; Myogenesis

In the proposed work we are attempting to understand the events underlying the development of cells that give rise to skeletal muscle in mammals. The commitment of cells to become specialized as muscle cells requires a particular ensemble of genes to be expressed which are required for these cells to have specialized functions such as being able to contract (allowing movement), to respond to nerve impulses from the nervous system (voluntary control of movement) and to function as a metabolic depot for the storage and combustion of energy substrates such as glucose and fats (metabolic control).

在拟议的工作中，我们试图了解哺乳动物骨骼肌细胞发育的潜在事件。细胞要成为特化的肌肉细胞，需要表达一组特定的基因，这些基因是细胞具有特化功能所必需的，比如能够收缩（允许运动），对神经系统的神经冲动做出反应（运动的自主控制），以及作为储存和燃烧能量底物（如葡萄糖和脂肪）的代谢仓库（代谢控制）。