Regulation of Leukocyte-Endothelial Interactions

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In vertebrate animals, white blood cells play an important role in the immune system by providing protection against bacterial, fungal, and viral infections. White blood cells patrol throughout the body looking for signs of infection. This immune cell surveillance involves interactions between white blood cells and the cells lining blood vessels. White cells are recruited to areas of injury by different signals, especially molecules called chemokines. Among the family of chemokines, one member, fractalkine, is found on the surface of cells lining blood vessels, and both attracts white cells and physically attaches them to blood vessels.