Regulation of Leukocyte-Endothelial Interactions

白细胞-内皮相互作用的调节

• 批准号: 418496-2012
• 负责人: Robinson, Lisa
• 金额: $ 2.48万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=551446
• 关键词: Regulation; Leukocyte; Endothelial; Interactions

In vertebrate animals, white blood cells play an important role in the immune system by providing protection against bacterial, fungal, and viral infections. White blood cells patrol throughout the body looking for signs of infection. This immune cell surveillance involves interactions between white blood cells and the cells lining blood vessels. White cells are recruited to areas of injury by different signals, especially molecules called chemokines. Among the family of chemokines, one member, fractalkine, is found on the surface of cells lining blood vessels, and both attracts white cells and physically attaches them to blood vessels.

在脊椎动物中，白色血细胞通过提供针对细菌、真菌和病毒感染的保护而在免疫系统中发挥重要作用。 白色血细胞在全身巡逻，寻找感染的迹象。 这种免疫细胞监视涉及白色血细胞和血管内衬细胞之间的相互作用。 白色细胞通过不同的信号，特别是称为趋化因子的分子，被招募到损伤区域。 在趋化因子家族中，有一个成员，fractalkine，存在于血管内衬细胞的表面，两者都能吸引白色细胞并将它们附着在血管上。