Regulation of NK cell biology by lung macrophage-derived interleukin-15

肺的气体交换功能对哺乳动物的生存至关重要。由于肺是对外开放的，它也是病原微生物的共同门户。因此，完整的先天防御系统守卫着肺，以确保其正常功能，但调节失调的先天防御系统会导致肺部感染和疾病。然而，我们对肺的先天免疫机制的了解仍然很粗略。这在一定程度上是因为传统上对个体先天免疫细胞类型的研究是孤立的，这不能反映哺乳动物动物肺中复杂的细胞间相互作用的情况。我们对肺天然免疫机制的了解有限，阻碍了对动物健康和肺部疾病的有效管理，以及改进的兽用疫苗和药物的开发。

The gas exchange function of the lung is essential to the survival of mammalian animals. As the lung is open to the outside world, it is also a common gateway to pathogenic microorganisms. Thus, the intact innate defense system guards the lung to ensure its normal function but dysregulated innate defense leads to lung infection and illness. However, our knowledge in the mechanisms of innate immunity in the lung remains sketchy. This is in part due to that individual innate immune cell types are traditionally studied in isolation, which does not reflect the situation of complex cell to cell interactions in the lung of mammalian animals. Our limited knowledge in the mechanisms of lung innate immunity hinders the effective management of animal health and lung disease, and the development of improved veterinary vaccines and medicines.