Iron metabolism and hepatitis C virus

铁代谢和丙型肝炎病毒

• 批准号: 288283-2011
• 负责人: Pantopoulos, Konstantinos
• 金额: $ 2.62万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506096
• 关键词: Iron; metabolism; hepatitis; virus

Infection with hepatitis C virus (HCV) poses a serious health care problem worldwide and is the leading cause of blood-transmitted chronic hepatitis, liver cirrhosis and hepatocellular cancer. The course of HCV infection is affected by various factors, including the body's iron status. Here we will employ a cell culture model for HCV replication (infectious "replicon") to study mechanisms by which HCV affects systemic and cellular iron homeostasis. We recently showed that administration of iron to HCV infected cells dramatically decreases viral replication. In earlier experiments, we also demonstrated that iron inhibits the function of the HCV RNA polymerase, a protein essential for viral replication. These findings are unexpected, considering that iron overload aggravates viral hepatitis C; thus, our data suggest that the adverse clinical effects of iron on HCV-infected patients are indirect.

丙型肝炎病毒（HCV）感染在世界范围内构成严重的卫生保健问题，并且是血液传播的慢性肝炎、肝硬化和肝细胞癌的主要原因。HCV感染的过程受各种因素的影响，包括身体的铁状态。在这里，我们将采用细胞培养模型的HCV复制（感染性“复制子”），研究机制，HCV影响系统和细胞铁稳态。我们最近表明，铁的管理，以HCV感染的细胞显着降低病毒复制。在早期的实验中，我们还证明了铁抑制HCV RNA聚合酶的功能，这是一种病毒复制所必需的蛋白质。这些发现是出乎意料的，考虑到铁超载加重病毒性丙型肝炎，因此，我们的数据表明，铁对HCV感染患者的不良临床影响是间接的。