Novel signalling motifs in macrophage patterm recognition receptors

巨噬细胞模式识别受体中的新信号基序

• 批准号: 386429-2010
• 负责人: Bowdish, Dawn
• 金额: $ 2.77万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506135
• 关键词: Novel; signalling; motifs; macrophage; patterm

Early in evolution single celled organisms developed a process called phagocytosis ("big-eating") in order to ingest food. This process was adapted for destroying competing organisms or pathogens, in essence by eating them and killing them through a process similar to digestion. In complex organisms such as ourselves, we have specialized amoeboid-like cells called macrophages that specialize in patrolling the tissues and phagocytosing/eating not only pathogens but also our own dead cells and waste products. Macrophages recognize their targets by surface bound proteins called receptors. When a macrophage encounters a potential target it must process and transmit a phenomenal amount of information including the size of the target, whether it is harmless or dangerous, and whether it can remove it or should recruit reinforcements. How it transmits this information is unclear and is the focus of this research program. This work will elucidate novel mechanisms of cellular signalling, increase our understanding on the evolution of phagocytosis and phagocytic receptors and has implications in many processes including host defence, homeostasis and embryonic development.

在进化的早期，单细胞生物发展了一种称为吞噬作用（“大吃”）的过程，以摄取食物。这一过程适用于消灭竞争性生物或病原体，本质上是通过类似于消化的过程吃掉它们并杀死它们。在像我们这样的复杂生物体中，我们有专门的阿米巴样细胞，称为巨噬细胞，专门负责巡逻组织，不仅吞噬/吃掉病原体，还吞噬我们自己的死亡细胞和废物。巨噬细胞通过被称为受体的表面结合蛋白识别它们的目标。当巨噬细胞遇到一个潜在的目标时，它必须处理和传递大量的信息，包括目标的大小，它是无害的还是危险的，以及它是否可以清除它或应该招募增援。它是如何传递这些信息的尚不清楚，这是这项研究计划的重点。这项工作将阐明细胞信号转导的新机制，增加我们对吞噬作用和吞噬受体的进化的理解，并在许多过程中，包括宿主防御，稳态和胚胎发育的影响。