Novel signalling motifs in macrophage patterm recognition receptors

巨噬细胞模式识别受体中的新信号基序

• 批准号: 386429-2010
• 负责人: Bowdish, Dawn
• 金额: $ 2.77万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506135
• 关键词: Novel; signalling; motifs; macrophage; patterm

Early in evolution single celled organisms developed a process called phagocytosis ("big-eating") in order to ingest food. This process was adapted for destroying competing organisms or pathogens, in essence by eating them and killing them through a process similar to digestion. In complex organisms such as ourselves, we have specialized amoeboid-like cells called macrophages that specialize in patrolling the tissues and phagocytosing/eating not only pathogens but also our own dead cells and waste products. Macrophages recognize their targets by surface bound proteins called receptors. When a macrophage encounters a potential target it must process and transmit a phenomenal amount of information including the size of the target, whether it is harmless or dangerous, and whether it can remove it or should recruit reinforcements. How it transmits this information is unclear and is the focus of this research program. This work will elucidate novel mechanisms of cellular signalling, increase our understanding on the evolution of phagocytosis and phagocytic receptors and has implications in many processes including host defence, homeostasis and embryonic development.

在进化中，单细胞生物在进化中开发了一个称为吞噬作用（“大吃一意”）的过程，以摄取食物。从本质上吃掉它们并通过类似于消化的过程将其杀死，从而使该过程适应了破坏竞争的生物或病原体。在像我们这样的复杂生物体中，我们拥有专门的变性细胞，称为巨噬细胞，专门巡逻组织和吞噬细胞/食用，不仅是病原体，而且还食用我们自己的死细胞和废物。巨噬细胞通过称为受体的表面结合蛋白来识别其靶标。当巨噬细胞遇到潜在的目标时，必须处理并传输出惊人数量的信息，包括目标的大小，无论是无害还是危险，以及它是否可以删除还是应招募增援。它如何传输此信息尚​​不清楚，并且是该研究计划的重点。这项工作将阐明细胞信号传导的新机制，增加我们对吞噬作用和吞噬受体的演变的理解，并在包括宿主防御，体内稳态和胚胎发育在内的许多过程中具有影响。