Remodeling of mammary tissue and lactation persistency / Remodelage de la glande mammaire et persistance de la lactation

乳腺组织重塑和泌乳持久性 / Remodelage de la lande mammaire et persistance de la milkation

• 批准号: 249618-2012
• 负责人: Lacasse, Pierre
• 金额: $ 1.6万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506257
• 关键词: Remodeling; mammary; tissue; lactation; persistency

The long range objectives of this research program are to improve our knowledge of the biological process involved in the control of mammary gland involution and to develop economically viable and consumer acceptable technologies or practices that would improve lactation persistency and enable longer lactation in dairy cows. Extended lactation would reduce the proportion of cow's lifetime spent in early lactation and, thus, the occurrence of disease, metabolic disorder and reproduction failure associated with this period. Apoptosis occurs in late lactation and accounts for the progressive loss of secretory cells in declining lactation. Therefore, there are considerable incentives to identify the factors which regulate mammary apoptosis.

这项研究计划的长期目标是提高我们对控制乳腺退化所涉及的生物过程的了解，并开发经济上可行且消费者可以接受的技术或实践，以改善奶牛的哺乳持久性，并使奶牛能够更长时间地哺乳。延长哺乳时间会减少奶牛在哺乳早期的生命比例，从而减少与这一时期相关的疾病、代谢紊乱和繁殖失败的发生。细胞凋亡发生在哺乳期晚期，是哺乳期下降时分泌细胞逐渐丧失的原因。因此，有相当大的动机来确定调控乳腺细胞凋亡的因素。