Remodeling of mammary tissue and lactation persistency / Remodelage de la glande mammaire et persistance de la lactation

乳腺组织重塑和泌乳持久性 / Remodelage de la lande mammaire et persistance de la milkation

• 批准号: 249618-2012
• 负责人: Lacasse, Pierre
• 金额: $ 1.6万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594293
• 关键词: Remodeling; mammary; tissue; lactation; persistency

The long range objectives of this research program are to improve our knowledge of the biological process involved in the control of mammary gland involution and to develop economically viable and consumer acceptable technologies or practices that would improve lactation persistency and enable longer lactation in dairy cows. Extended lactation would reduce the proportion of cow's lifetime spent in early lactation and, thus, the occurrence of disease, metabolic disorder and reproduction failure associated with this period. Apoptosis occurs in late lactation and accounts for the progressive loss of secretory cells in declining lactation. Therefore, there are considerable incentives to identify the factors which regulate mammary apoptosis.

该研究计划的远距离目标是提高我们对控制乳腺互动控制的生物学过程的了解，并开发经济可行且消费者可接受的技术或实践，以改善哺乳期持久性并在奶牛中实现更长的泌乳。延长的泌乳将减少牛早期哺乳期花费的比例，从而减少疾病，代谢障碍和与这一时期相关的繁殖失败的发生。凋亡发生在晚期泌乳中，并解释了分泌细胞在泌乳下降时的进行性丧失。因此，有大量激励措施确定调节乳腺凋亡的因素。