Spindles of insect viruses: structure, function and engineering of natural protein crystals as microparticles for vaccine delivery

昆虫病毒纺锤体：天然蛋白质晶体作为疫苗递送微粒的结构、功能和工程

• 批准号: DP120104039
• 负责人: Prof Fasseli Coulibaly
• 金额: $ 22.6万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-03 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120104039
• 关键词: Spindles; insect; viruses; structure; function

Protein self-assembly is a critical process participating to the cell architecture and molecular machinery. This project will study the molecular structure of crystals forming in virally-infected cells, a striking example of protein self-assembly, and will engage in engineering of novel crystalline microparticles as antiviral vaccines.

蛋白质自组装是参与细胞结构和分子机制的重要过程。该项目将研究病毒感染细胞中形成的晶体的分子结构，这是蛋白质自组装的一个突出例子，并将从事新型结晶微粒作为抗病毒疫苗的工程。