The physiological roles of PAPPA2

PAPPA2的生理作用

• 批准号: 326791-2011
• 负责人: Christians, Julian
• 金额: $ 2.26万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506670
• 关键词: physiological; roles; PAPPA2

The goal of my research is to understand the physiological and genetic factors underlying within-species variation in continuous traits such as body size. In previous work, I identified the PAPPA2 gene as potentially important for controlling variation in growth in mice. Little is known about PAPPA2, but a structurally related gene, PAPPA, is important in a variety of processes including pregnancy, bone development, cardiovascular disease, skin healing and aging.

我的研究目标是了解物种内连续性状（如体型）变异的生理和遗传因素。在之前的工作中，我确定了PAPPA2基因在控制小鼠生长变异方面具有潜在的重要作用。人们对PAPPA2知之甚少，但与PAPPA结构相关的基因PAPPA在妊娠、骨骼发育、心血管疾病、皮肤愈合和衰老等多种过程中都很重要。