Modeling of radiation dose deposition in time-varying geometries

时变几何结构中辐射剂量沉积的建模

• 批准号: 402092-2011
• 负责人: Heath, Emily
• 金额: $ 1.46万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=507324
• 关键词: Modeling; radiation; dose; deposition; time

The aim of radiation therapy is to deliver a high dose of ionizing radiation to destroy malignant tumor cells while sparing the surrounding healthy tissue to avoid treatment-related side effects. Traditionally, radiation therapy treatment planning has assumed that the patient's geometry remains static during the treatment delivery. However, it is known that the internal anatomy undergoes significant motion and deformation due to respiratory motion which can result in blurring and distortion of the delivered dose distribution.

放射治疗的目的是提供高剂量的电离辐射来摧毁恶性肿瘤细胞，同时保留周围的健康组织，以避免与治疗相关的副作用。传统上，放射治疗计划假定患者的几何形状在治疗过程中保持不变。然而，众所周知，由于呼吸运动，内部解剖结构经历了显著的运动和变形，这可能导致传递剂量分布的模糊和扭曲。