Regulation of PNKP and XRCC4 in non-homologous end-joining by dynamic, reversible protein phosphorylation.
Regulation of PNKP and XRCC4 in non-homologous end-joining by dynamic, reversible protein phosphorylation.
批准号:
253967
负责人:
Lees-Miller Susan P
金额:
$71.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-03-01 至 2017-03-01
中文摘要
电离辐射(IR)被广泛应用于多种癌症的治疗。它的作用是诱导致命的DNA损伤,特别是一种称为DNA双链断裂或DSB的形式。IR诱导的DSB在人细胞内修复的主要途径是
英文摘要
Ionizing radiation (IR) is used extensively in the treatment of many forms of cancer. It acts by inducing lethal DNA damage, in particular a form called a DNA double strand break or DSB. The major pathway for the repair of IR-induced DSBs in human cells i
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