Molecular chronobiology in dinoflagellates
甲藻的分子时间生物学
基本信息
- 批准号:171382-2008
- 负责人:
- 金额:$ 5.84万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2012
- 资助国家:加拿大
- 起止时间:2012-01-01 至 2013-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
What makes a cell or an organism able to do some things better at a particular time of day or night? Generally speaking, the daily behavior of most organisms is regulated by an internal timer termed a circadian clock. This clock serves to predict daily environmental changes and to adjust cellular physiology and biochemistry in consequence. Our interest lies to cataloging the range of strategies by which cells modulate their behavior. We use a single celled organism as a model, which is easy to grow in culture and has many different rhythms. We have chosen four different rhythms for detailed study, and are trying to relate changes in cellular biochemistry with the rhythms that we observe. In the simplest strategy we have characterized, the cell makes a particular reaction go faster by synthesizing more enzyme. In another, more complicated strategy, the cell makes a reaction go faster by changing the distribution of an enzyme in the cell. While the specifics of the reactions may be restricted to our model system, the general strategies uncovered may be generally applicable to other systems including humans.
是什么让一个细胞或一个有机体能够在白天或晚上的特定时间做得更好?一般来说,大多数生物体的日常行为是由称为生物钟的内部计时器调节的。这个生物钟用来预测每天的环境变化,从而调整细胞的生理和生物化学。我们的兴趣在于对细胞调节其行为的策略范围进行编目。我们使用单细胞生物作为模型,它很容易在培养基中生长,并且有许多不同的节奏。我们选择了四种不同的节奏进行详细的研究,并试图将细胞生物化学的变化与我们观察到的节奏联系起来。在我们所描述的最简单的策略中,细胞通过合成更多的酶来加快特定的反应。在另一种更复杂的策略中,细胞通过改变细胞中酶的分布来加快反应速度。虽然反应的细节可能仅限于我们的模型系统,但所揭示的一般策略可能普遍适用于包括人类在内的其他系统。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Morse, David其他文献
Degradation of S-RNase in compatible pollen tubes of Solanum chacoense inferred by immunogold labeling
- DOI:
10.1242/jcs.154823 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:4
- 作者:
Boivin, Nicolas;Morse, David;Cappadocia, Mario - 通讯作者:
Cappadocia, Mario
Cold-Induced Cysts of the Photosynthetic Dinoflagellate Lingulodinium polyedrum Have an Arrested Circadian Bioluminescence Rhythm and Lower Levels of Protein Phosphorylation
- DOI:
10.1104/pp.113.229856 - 发表时间:
2014-02-01 - 期刊:
- 影响因子:7.4
- 作者:
Roy, Sougata;Letourneau, Louis;Morse, David - 通讯作者:
Morse, David
Circadian photosynthetic reductant flow in the dinoflagellate Lingulodinium is limited by carbon availability
- DOI:
10.1111/j.1365-3040.2010.02271.x - 发表时间:
2011-04-01 - 期刊:
- 影响因子:7.3
- 作者:
MacKenzie, Tyler D. B.;Morse, David - 通讯作者:
Morse, David
S-Phase and M-phase timing are under independent circadian control in the dinoflagellate Lingulodinium
- DOI:
10.1177/0748730408321749 - 发表时间:
2008-10-01 - 期刊:
- 影响因子:3.5
- 作者:
Dagenais-Bellefeuille, Steve;Bertomeu, Thierry;Morse, David - 通讯作者:
Morse, David
Strategies to Improve Case Outcome When Referral Is Not Affordable
- DOI:
10.3138/jvme.0518-061r1 - 发表时间:
2020-06-01 - 期刊:
- 影响因子:1
- 作者:
Sullivant, Alyssa M.;Mackin, Andrew J.;Morse, David - 通讯作者:
Morse, David
Morse, David的其他文献
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{{ truncateString('Morse, David', 18)}}的其他基金
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2022
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2021
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2020
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2019
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2018
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
甲藻分子生物学和昼夜节律机制
- 批准号:
171382-2013 - 财政年份:2017
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
甲藻分子生物学和昼夜节律机制
- 批准号:
171382-2013 - 财政年份:2016
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
甲藻分子生物学和昼夜节律机制
- 批准号:
171382-2013 - 财政年份:2015
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
甲藻分子生物学和昼夜节律机制
- 批准号:
171382-2013 - 财政年份:2014
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Dinoflagellate Molecular Biology and Mecanisms of Circadian Rhythms
甲藻分子生物学和昼夜节律机制
- 批准号:
171382-2013 - 财政年份:2013
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2022
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2021
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2020
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2019
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular Chronobiology and regulation of gene expression in dinoflagellates
甲藻的分子时间生物学和基因表达调控
- 批准号:
RGPIN-2018-04220 - 财政年份:2018
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular chronobiology in dinoflagellates
甲藻的分子时间生物学
- 批准号:
171382-2008 - 财政年份:2011
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular chronobiology in dinoflagellates
甲藻的分子时间生物学
- 批准号:
364386-2008 - 财政年份:2010
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Molecular chronobiology in dinoflagellates
甲藻的分子时间生物学
- 批准号:
171382-2008 - 财政年份:2010
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual
Molecular chronobiology in dinoflagellates
甲藻的分子时间生物学
- 批准号:
364386-2008 - 财政年份:2009
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Molecular chronobiology in dinoflagellates
甲藻的分子时间生物学
- 批准号:
171382-2008 - 财政年份:2009
- 资助金额:
$ 5.84万 - 项目类别:
Discovery Grants Program - Individual