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Studies on proteases and biofilm formation: two potential critical factors in the pathogenesis of Streptococcus suis

蛋白酶和生物膜形成的研究：猪链球菌发病机制中的两个潜在关键因素

基本信息

批准号：
194703-2009
负责人：
Grenier, Daniel
金额：
$ 2.96万
依托单位：
Université Laval
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514047
关键词：
Studies proteases biofilm formation two

项目摘要

Streptococcus suis, a major swine pathogen worldwide, is transmitted via the respiratory route and colonizes the palatine tonsils of pigs. Major infections caused by this pathogen include septicemiae, meningitis and endocarditis. These bacterial infections generate important economic losses to the Canadian swine industry. The mechanisms by which S. suis invades and infects the host are still unclear even though numerous studies on potential virulence factors have been carried out over the past decade. The research program of my laboratory is based on our central hypothesis that host-bacteria interactions play a critical role in the pathogenesis of S. suis infections and focuses on protease activities and biofilm formation. Our laboratory is the first to study these two relevant aspects in S. suis infections. In this application, we propose to further investigate these properties of S. suis and to provide evidences for their contribution to the infectious process. Our research program has two complementary objectives: (i) increase our basic knowledge of the virulence determinants of the swine pathogen S. suis, and (ii) use this knowledge to identify new candidate vaccines or therapeutic targets to control S. suis infections.

猪链球菌是世界范围内的主要猪病原体，通过呼吸道传播并定植于猪的腭扁桃体。这种病原体引起的主要感染包括败血症、脑膜炎和心内膜炎。这些细菌感染给加拿大养猪业造成了重大的经济损失。尽管过去十年对潜在毒力因子进行了大量研究，但猪链球菌入侵和感染宿主的机制仍不清楚。我实验室的研究计划基于我们的中心假设，即宿主与细菌的相互作用在猪链球菌感染的发病机制中发挥着关键作用，并重点关注蛋白酶活性和生物膜形成。我们的实验室是第一个研究猪链球菌感染这两个相关方面的实验室。在本申请中，我们建议进一步研究猪链球菌的这些特性，并为其对感染过程的贡献提供证据。我们的研究计划有两个互补的目标：（i）增加我们对猪病原体猪链球菌毒力决定因素的基础知识，以及（ii）利用这些知识来确定新的候选疫苗或治疗靶点来控制猪链球菌感染。