Advanced techniques for organic analysis

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The research proposed aims at the development of new and improved techniques for the analysis of organic compounds. The main thrust of the research will be the advancement of high efficiency and multidimensional separations, including comprehensive two-dimensional gas chromatography (GC×GC) and liquid chromatography (LC×LC). In these techniques, components of the samples are subject to separation in two separate columns ("dimensions") characterized by different properties. This vastly increases the chance that components that could not be separated in one column will be separated in the second one. In addition, the total number of components that can be separated in a single analysis is dramatically increased. The goals of the research include increasing the speed and efficiency of the separations through novel approaches. In GCxGC, we plan to continue the development of a novel thermal modulator (interface between the columns) which does not require any consumables. We will also explore incorporation of programmed temperature cooling to improve transfer of semi-volatile compounds to the second column.