Cellular mechanisms and network dynamics of hippocampal sharp waves

海马尖波的细胞机制和网络动力学

• 批准号: 217479-2010
• 负责人: Zhang, Liang
• 金额: $ 3.06万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514208
• 关键词: Cellular; mechanisms; network; dynamics; hippocampal

The brain manifests electrographic activities that are tightly linked with behaviors and implicated in cognitive functions. Understanding these electrographic activities is a major task of neurobiology. The goal of our research is to reveal the mechanisms of electrographic activities in the hippocampus, a limbic structure crucial for learning and memory. Particularly, we focus on hippocampal sharp waves (SPWs) and use the mouse hippocampus as a model system.

大脑表现出的电图活动与行为密切相关，并涉及认知功能。了解这些电图活动是神经生物学的一项主要任务。我们研究的目的是揭示海马体中电活动的机制，海马体是一个对学习和记忆至关重要的边缘结构。特别是，我们关注海马锐波（SPWs），并使用小鼠海马作为模型系统。