Interactions and molecular organization in polymer surfactant systems

聚合物表面活性剂体系中的相互作用和分子组织

• 批准号: 261514-2008
• 负责人: Allen, Christine
• 金额: $ 3.35万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514590
• 关键词: Interactions; molecular; organization; polymer; surfactant

Polymer-surfactant pairs play a critical role in many cosmetic and agriculture products as well as paint and pharmaceutical formulations. The high molecular weight polymers and low molecular weight surfactants are often combined to take advantage of their unique and synergistic properties; for example, the mechanical properties of the polymer and self-assembly behavior of the surfactant. However, polymer-surfactant systems have not been fully exploited for use in biomedical and pharmaceutical applications due to the lack of information available on combinations of biopolymers and nonionic surfactants. To date, most of the fundamental studies on polymer-surfactant systems have included charged surfactants (e.g. sodium dodecyl sulfate) which have limited potential for use in biomedical applications due to their poor safety and toxicity profiles. In this way, the selection of appropriate biopolymer- nonionic surfactant pairs for biomedical applications often proceeds by trial and error.

聚合物-表面活性剂对在许多化妆品和农业产品以及涂料和药物配方中起着关键作用。 通常将高分子量聚合物和低分子量表面活性剂组合以利用其独特的和协同的性质;例如，聚合物的机械性质和表面活性剂的自组装行为。然而，聚合物-表面活性剂系统尚未被充分开发用于生物医学和制药应用，由于缺乏关于生物聚合物和非离子表面活性剂的组合的可用信息。 迄今为止，大多数关于聚合物-表面活性剂体系的基础研究都包括带电表面活性剂（例如十二烷基硫酸钠），由于其不良的安全性和毒性特征，其在生物医学应用中的应用潜力有限。 以这种方式，用于生物医学应用的适当的生物聚合物-非离子表面活性剂对的选择通常通过试验和错误来进行。