Testosterone action in the sexual differentiation of the mammalian nervous system and behaviour

睾酮在哺乳动物神经系统和行为的性别分化中的作用

• 批准号: 312458-2011
• 负责人: Monks, Douglas
• 金额: $ 2.91万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514909
• 关键词: Testosterone; action; sexual; differentiation; mammalian

There are many sex differences in the structure and function of the mammalian nervous system. Sex differences homologous to those in humans are also found in the nervous system and behaviour of laboratory rodents, providing an opportunity to study experimentally the processes that result in sex differences. Of the many sex differences identified in the rodent nervous system, only one has an unambiguous function and has been studied sufficiently that we have a clear model to explain its sexual differentiation. The spinal nucleus of the bulbocavernosus (SNB) is a neuromuscular system mediating sexual reflexes and has been exceptionally successful in uncovering general principles of sexual differentiation that are thought to apply generally to the nervous system.

哺乳动物神经系统的结构和功能有许多性别差异。在实验室啮齿类动物的神经系统和行为中也发现了与人类相似的性别差异，这为实验研究导致性别差异的过程提供了机会。在啮齿类动物神经系统的许多性别差异中，只有一种具有明确的功能，并且已经被充分研究，我们有一个清晰的模型来解释其性别分化。球海绵体脊髓核（SNB）是一个介导性反射的神经肌肉系统，在揭示被认为普遍适用于神经系统的性别分化的一般原则方面非常成功。