Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry
Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry
批准号:
327028-2009
负责人:
Mittermaier, Anthony
金额:
$3.64万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31
中文摘要
蛋白质在各种各样的细胞过程中扮演着核心角色,因此了解它们的功能对于理解生命的分子基础至关重要。蛋白质是高度灵活的分子,越来越多的证据表明,它们的内部动力学在它们的生物活动中起着至关重要的作用,但人们对它的了解仍然很少。我们将使用三种互补的生物物理技术来将蛋白质分子的内部运动与其功能联系起来:核磁共振(NMR),等温滴定量热法(ITC)和差示扫描量热法(DSC)。
英文摘要
Proteins are central players in an enormous variety of cellular processes, thus understanding how they function is critical to understanding the molecular basis of life. Proteins are highly flexible molecules, and there is growing evidence that their internal dynamics play an essential, but still poorly understood, role in their biological activities. We will use three complementary biophysical techniques to relate the internal motions of protein molecules to their function: Nuclear magnetic resonance (NMR), isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DNA dynamics in biology and technology
-
批准号:RGPIN-2022-03242
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$4.52万
-
财政年份:2022
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2021
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2020
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2019
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2018
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2017
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2016
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2015
-
负责人:Mittermaier, Anthony
-
依托单位:
Binding Mechanisms and Conformational Equilibria in Biomacromolecular Interactions
-
批准号:RGPIN-2014-05776
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.93万
-
财政年份:2014
-
负责人:Mittermaier, Anthony
-
依托单位:
Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry
-
批准号:327028-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2013
-
负责人:Mittermaier, Anthony
-
依托单位:
Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry
-
批准号:327028-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2011
-
负责人:Mittermaier, Anthony
-
依托单位:
Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry
-
批准号:327028-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2010
-
负责人:Mittermaier, Anthony
-
依托单位:
Quantifying the dynamics of protein function at the atomic level using NMR and calorimetry
-
批准号:327028-2009
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2009
-
负责人:Mittermaier, Anthony
-
依托单位:
Engineering protein dynamics and function using NMR, mutagenesis, and calorimetry
-
批准号:327028-2006
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.78万
-
财政年份:2008
-
负责人:Mittermaier, Anthony
-
依托单位:
High field NMR spectrometer for chemical biology research
-
批准号:360010-2008
-
项目类别:Research Tools and Instruments - Category 1 (<$150,000)
-
资助金额:$10.93万
-
财政年份:2007
-
负责人:Mittermaier, Anthony
-
依托单位:
Engineering protein dynamics and function using NMR, mutagenesis, and calorimetry
-
批准号:327028-2006
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.78万
-
财政年份:2007
-
负责人:Mittermaier, Anthony
-
依托单位:
Engineering protein dynamics and function using NMR, mutagenesis, and calorimetry
-
批准号:327028-2006
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.78万
-
财政年份:2006
-
负责人:Mittermaier, Anthony
-
依托单位:
Differential scanning calorimeter for studying the thermodynamics of protein folding
-
批准号:330931-2006
-
项目类别:Research Tools and Instruments - Category 1 (<$150,000)
-
资助金额:$7.46万
-
财政年份:2005
-
负责人:Mittermaier, Anthony
-
依托单位:
Studying protein dynamics by computer simulation: incorporation of NMR data
-
批准号:267865-2003
-
项目类别:Postdoctoral Fellowships
-
资助金额:$0.49万
-
财政年份:2005
-
负责人:Mittermaier, Anthony
-
依托单位:
Studying protein dynamics by computer simulation: incorporation of NMR data
-
批准号:267865-2003
-
项目类别:Postdoctoral Fellowships
-
资助金额:$2.91万
-
财政年份:2004
-
负责人:Mittermaier, Anthony
-
依托单位:
国内基金
海外基金
登录
查看更多内容
发展基因编码的荧光探针揭示趋化因子CXCL10的时空动态及其调控机制
-
批准号:32371150
-
项目类别:面上项目
-
资助金额:50.00万元
-
批准年份:2023
-
负责人:井淼
-
依托单位:
β-arrestin2- MFN2-Mitochondrial Dynamics轴调控星形胶质细胞功能对抑郁症进程的影响及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:
-
依托单位:
用于对微管动态结构实时定量分析的荧光探针
-
批准号:32070708
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:谢松波
-
依托单位:
钱江潮汐影响下越江盾构开挖面动态泥膜形成机理及压力控制技术研究
-
批准号:LY21E080004
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2020
-
负责人:尹鑫晟
-
依托单位:
层状半导体材料纳米结构中激子分离动力学研究
-
批准号:22073022
-
项目类别:面上项目
-
资助金额:63.0万元
-
批准年份:2020
-
负责人:刘新风
-
依托单位:
磁性薄膜和磁性纳米结构中的自旋动力学研究
-
批准号:11174131
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2011
-
负责人:游彪
-
依托单位:
星系结构基本单元星团的研究
-
批准号:11043006
-
项目类别:专项基金项目
-
资助金额:10.0万元
-
批准年份:2010
-
负责人:理查德迪何瑞斯
-
依托单位:
星系恒星与气体的动力学演化
-
批准号:11073025
-
项目类别:面上项目
-
资助金额:30.0万元
-
批准年份:2010
-
负责人:RainerSpurzem
-
依托单位:
在我们的门前发掘化石——利用中国即将开展的巡天来研究银河系的演化
-
批准号:11043005
-
项目类别:专项基金项目
-
资助金额:10.0万元
-
批准年份:2010
-
负责人:马丁史密斯
-
依托单位:
物体运动对流场扰动的数学模型研究
-
批准号:51072241
-
项目类别:专项基金项目
-
资助金额:10.0万元
-
批准年份:2010
-
负责人:李廷秋
-
依托单位: