Lung micromechanical modelling using in vivo regional pulmonary functional magnetic resonance imaging

使用体内局部肺功能磁共振成像进行肺微机械建模

基本信息

  • 批准号:
    402091-2011
  • 负责人:
  • 金额:
    $ 4.15万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2012
  • 资助国家:
    加拿大
  • 起止时间:
    2012-01-01 至 2013-12-31
  • 项目状态:
    已结题

项目摘要

Recent advances in imaging methods dedicated to the lung include methods that involve inhaled gases that provide a unique magnetic resonance imaging (MRI) signal or contrast. These novel MRI methods as based on the magnetization (or hyperpolarization) of noble gases such as 3He and 129Xe and have been pioneered at a handful of imaging research centres (including ours) for measurements of lung function that until now have never been possible. The traditional view of lung function and mechanics has been derived from simple 2 compartment models and measurements developed using pressure and flow measurements at the mouth or tubes fixed to the end of the trachea of excised lungs. Despite the importance of these traditional approaches, it has unfortunately, not yet been possible to incorporate regional lung information to better develop lung models of function and mechanics. To directly address this decades-old problem, we propose to incorporate lung imaging measurements of airway and airspace structure and function into existing models of lung micromechanics and to develop new models and test these using regional functional imaging information. Therefore the overarching objective of our proposed research program is to develop new ways to use lung tissue and airway functional and structural quantitative measurements derived from 3He and 129Xe MR images in obstructive lung disease like asthma and COPD as well as healthy volunteers to generate and develop robust mathematical models of the biomechanics in healthy and diseased lung. This approach provides a way to incorporate, test and validate regional in vivo imaging measurements to generate novel micromechanical models of the lung.
专用于肺的成像方法的最新进展包括涉及提供独特的磁共振成像(MRI)信号或对比度的吸入气体的方法。 这些新的MRI方法是基于惰性气体如3He和129He的磁化(或超极化),并已在少数成像研究中心(包括我们)率先用于测量肺功能,直到现在还不可能。 肺功能和力学的传统观点来源于简单的2室模型和测量,这些模型和测量是使用固定到切除肺的气管末端的口部或管处的压力和流量测量而开发的。 尽管这些传统方法的重要性,但不幸的是,还不可能结合局部肺信息以更好地开发肺功能和力学模型。 为了直接解决这个几十年的老问题,我们建议将肺成像测量气道和空域的结构和功能纳入现有的肺微观力学模型,并开发新的模型和测试这些使用区域功能成像信息。 因此,我们提出的研究计划的总体目标是开发新的方法来使用肺组织和气道功能和结构的定量测量来自3He和129HNMR图像阻塞性肺病,如哮喘和COPD以及健康志愿者,以生成和开发健康和患病肺的生物力学的强大的数学模型。这种方法提供了一种方法来合并,测试和验证区域在体内成像测量,以生成新的肺的微机械模型。

项目成果

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Parraga, Grace其他文献

Scan-rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T
  • DOI:
    10.1088/0031-9155/53/23/011
  • 发表时间:
    2008-12-07
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Vidal, Arvin;Bureau, Yves;Parraga, Grace
  • 通讯作者:
    Parraga, Grace
Ultra-short Echo-Time Pulmonary MRI: Evaluation and Reproducibility in COPD Subjects With and Without Bronchiectasis
  • DOI:
    10.1002/jmri.24680
  • 发表时间:
    2015-05-01
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Ma, Weijing;Sheikh, Khadija;Parraga, Grace
  • 通讯作者:
    Parraga, Grace
Hyperpolarized 3He Magnetic Resonance Functional Imaging Semiautomated Segmentation
  • DOI:
    10.1016/j.acra.2011.10.007
  • 发表时间:
    2012-02-01
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Kirby, Miranda;Heydarian, Mohammadreza;Parraga, Grace
  • 通讯作者:
    Parraga, Grace
Is Computed Tomography Airway Count Related to Asthma Severity and Airway Structure and Function?
Hyperpolarized 3He magnetic resonance imaging of ventilation defects in healthy elderly volunteers:: Initial findings at 3.0 Tesla
  • DOI:
    10.1016/j.acra.2008.03.003
  • 发表时间:
    2008-06-01
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Parraga, Grace;Mathew, Lindsay;Santyr, Giles E.
  • 通讯作者:
    Santyr, Giles E.

Parraga, Grace的其他文献

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{{ truncateString('Parraga, Grace', 18)}}的其他基金

Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    RGPIN-2016-04760
  • 财政年份:
    2022
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Individual
Novel, Non-invasive Multi-spectral, Multi-compartment 129Xe MR Gas-exchange Measurements: MUCXE
新型、非侵入性多光谱、多室 129Xe MR 气体交换测量:MUCXE
  • 批准号:
    RTI-2023-00087
  • 财政年份:
    2022
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Research Tools and Instruments
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    RGPIN-2016-04760
  • 财政年份:
    2021
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Individual
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    RGPIN-2016-04760
  • 财政年份:
    2020
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Individual
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    RGPIN-2016-04760
  • 财政年份:
    2019
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Individual
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    493150-2016
  • 财政年份:
    2018
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    RGPIN-2016-04760
  • 财政年份:
    2018
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Individual
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    RGPIN-2016-04760
  • 财政年份:
    2017
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Individual
Inhaled gas and Ultra-short/zero-echo time MRI of pulmonary airways and airspaces for modelling the morphometry and biomechanical properties of pulmonary parenchyma and airways
吸入气体和肺气道和空腔的超短/零回波时间 MRI,用于模拟肺实质和气道的形态测量和生物力学特性
  • 批准号:
    493150-2016
  • 财政年份:
    2017
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
129Xe MRI radiofrequency coil for in vivo measurements of airways and alveoli to generate novel lung biomechanical models
129Xe MRI 射频线圈用于气道和肺泡的体内测量,以生成新型肺生物力学模型
  • 批准号:
    RTI-2017-00240
  • 财政年份:
    2016
  • 资助金额:
    $ 4.15万
  • 项目类别:
    Research Tools and Instruments

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使用体内局部肺功能磁共振成像进行肺微机械建模
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使用体内局部肺功能磁共振成像进行肺微机械建模
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使用体内局部肺功能磁共振成像进行肺微机械建模
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