The hypoxic brain: implications for breathing stability

大脑缺氧：对呼吸稳定性的影响

• 批准号: 405654-2011
• 负责人: Willie, Christopher
• 金额: $ 3.64万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Vanier Canada Graduate Scholarships - Doctoral
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=515558
• 关键词: hypoxic; brain; implications; breathing; stability

Blood flow to the brain needs to be tightly controlled because too much or too little blood flow can lead to unconsciousness, stroke, and impairment to breathing regulation. Sadly, the mechanisms by which the human body controls both brain blood flow and breathing are very poorly understood. This research aims to elucidate these mechanisms using high altitude as a means to alter oxygen supply to the brain. It is a fascinating phenomenon that breathing regulation in humans, especially during sleep, becomes severely unstable with ascent to high altitude. This makes it a convenient environment in which to pharmacologically manipulate brain blood flow in order to study the resultant changes to breathing control. Specifically this research aims (1) to elucidate these control mechanisms that are necessary for survival and yet are largely not understood, and also (2) to understand mammalian adaptation to hypoxic environments. These basic questions in human physiology are essential in the effort to treat and prevent age- and disease-associated declines in brain function, and diseases that effect breathing in humans.

需要严格控制流向大脑的血流，因为血流过多或过少都会导致意识丧失、中风和呼吸调节障碍。可悲的是，人体控制脑血流和呼吸的机制知之甚少。 这项研究旨在阐明这些机制，使用高海拔作为改变大脑氧气供应的手段。这是一个有趣的现象，人类的呼吸调节，特别是在睡眠期间，随着上升到高海拔而变得严重不稳定。 这使得它成为一个方便的环境，可以在其中模拟操纵脑血流，以研究呼吸控制的结果变化。 具体来说，这项研究的目的是（1）阐明这些控制机制，是必要的生存，但在很大程度上是不理解的，也（2）了解哺乳动物适应缺氧环境。人类生理学中的这些基本问题对于治疗和预防与年龄和疾病相关的脑功能下降以及影响人类呼吸的疾病至关重要。