Molecular pathways involved in epithelial-to-mesenchymal-like transition as therapeutic targets and prognostic markers of cartilage degradation in rheumatoid arthritis

参与上皮-间质样转变的分子途径作为类风湿性关节炎软骨退化的治疗靶点和预后标志物

• 批准号: 274860
• 负责人: Dubois Claire M
• 金额: $ 7.29万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=274860&lang=en
• 关键词: Cartilage Degradation; Cell Invasion; Collagen-Induced Arthritis (Cia); Confocal Microscopy; Epthelial-Mesenchymal Transition; Immunohistochemistry; Invadopodia; Rheumatoid Arthritis; Tissue Transglutaminase; Transforming Growth Factor Beta

Rheumatoid arthritis leads to rapid destruction of cartilage and bone in a large proportion of patients, leading to severe functional disabilities. The molecular mechanisms underlying disease severity and destructive progression are poorly characterized,

风湿性关节炎导致大部分患者的软骨和骨骼迅速破坏，导致严重的功能障碍。 疾病严重程度和破坏性进展的分子机制特征不清楚，