Hypoxic control of tumor cell invasion and metastasis

低氧控制肿瘤细胞侵袭和转移

• 批准号: 266494
• 负责人: Dubois Claire M
• 金额: $ 53.89万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=266494&lang=en
• 关键词: Cancer; Furin; Hypoxia; Invadopodia; Lysosome Trafficking; Metastasis; Nhe-1

For cancer cells to grow and make metastasis they have to degrade the surrounding tissues, a process that is influence by a particular microenvironment of the tumor that is the lack of oxygen which triggers acidosis. Growing evidence connects newly ident

为了让癌细胞生长和转移，它们必须降解周围的组织，这一过程受到肿瘤特定微环境的影响，即缺氧引发酸中毒。越来越多的证据将新身份联系起来