SMN and Post-transcriptional Regulation in Motor Neurons: Implications for Spinal Muscular Atrophy

SMN 和运动神经元转录后调节：对脊髓性肌萎缩症的影响

• 批准号: 266847
• 负责人: Côt Jocelyn
• 金额: $ 51.21万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=266847&lang=en
• 关键词: Arginine Methylation; Cellular And Animal Models; Motor Neurons; Neuromuscular Junction; Post-Transcriptional Regulation Of Gene Expression; Protein Arginine Methyltransferases; Rna Binding Proteins; Rna Granules; Spinal Muscular Atrophy; Tudor Domain

Loss of a protein named SMN (for 'Survival of Motor Neurons') is responsible for spinal muscular atrophy, a disease that affects 1 in every 10000 newborns and is the leading genetic cause of infant mortality. It is characterized by a degeneration of the m

一种名为SMN（运动神经元的存活）的蛋白质的丢失是脊髓性肌萎缩症的原因，这种疾病每10000名新生儿中就有1人患病，是婴儿死亡的主要遗传原因。它的特点是m的退化