Tribological Stimulation of Agarose/Chondrocyte Constructs for Tissue Engineering Applications

用于组织工程应用的琼脂糖/软骨细胞结构的摩擦学刺激

• 批准号: 1660-2013
• 负责人: Medley, John
• 金额: $ 1.89万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=520414
• 关键词: Tribological; Stimulation; Agarose; Chondrocyte; Constructs

About 4 million Canadians have osteoarthritic damage to the articular cartilage surfaces of one or more of their joints. For some, this age-related disease progresses slowly without much restriction to their activities but in others it rapidly reaches an end-stage condition where mobility is severely impaired and the joint itself is totally destroyed. The only current treatment is to replace the joint with an inert, somewhat less functional, implant. Each year, about 80,000 joints are replaced in Canada.

大约有400万加拿大人的一个或多个关节的关节软骨表面有骨关节炎损伤。对于一些人来说，这种与年龄有关的疾病进展缓慢，对他们的活动没有太多限制，但在其他人中，它迅速达到终末期状态，其中活动性严重受损，关节本身完全被破坏。目前唯一的治疗方法是用一种惰性的、功能稍差的植入物代替关节。加拿大每年约有8万个关节被更换。