Signalling and cell walls

信号传导和细胞壁

• 批准号: 101519-2011
• 负责人: Ellis, Brian
• 金额: $ 4.74万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521892
• 关键词: Signalling; cell; walls

My research program focuses on two aspects of plant biology: how plants use specific signaling modules to detect and respond to environmental and developmental cues, how plants build their complex polysaccharide cell walls, and how these two phenomena are connected. The cellular mechanisms by which plants successfully respond to environmental challenges are controlled by signal switching mechanisms such as protein phosphorylation/de-phosphorylation cycles, catalyzed by protein kinases. The mitogen-activated protein kinase (MAPK) family of enzymes plays a central role in these switching systems, but we know little about the biological functions of the Group D sub-family of MAPKs. We will use a combination of genetics, cell biology, genomics and biochemistry to identify the full range of cellular processes that Group D MPKs are controlling in Arabidopsis.

我的研究项目主要集中在植物生物学的两个方面：植物如何使用特定的信号模块来检测和响应环境和发育线索，植物如何构建其复杂的多糖细胞壁，以及这两种现象是如何连接的。植物成功应对环境挑战的细胞机制是由信号转换机制控制的，如蛋白激酶催化的蛋白磷酸化/去磷酸化循环。丝裂原活化蛋白激酶（MAPK）家族在这些开关系统中起着核心作用，但我们对D组MAPK亚家族的生物学功能知之甚少。我们将使用遗传学，细胞生物学，基因组学和生物化学的组合，以确定全方位的细胞过程中，D组MPKs控制拟南芥。