Transgenerational Effects of Antenatal Glucocorticoid Treatment: Mechanisms of Programming

产前糖皮质激素治疗的跨代效应：编程机制

• 批准号: 266834
• 负责人: Matthews Stephen G
• 金额: $ 57.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=266834&lang=en
• 关键词: Antenatal Glucocorticoids; Development; Dna Methylation; Epigenetics; Hypothalamo-Pituitary-Adrenal Axis; Pregnancy; Preterm Labour; Transgenerational

Approximately 10% of pregnant women are treated with glucocorticoid (GC) in late gestation, to promote lung maturation in babies at risk of preterm delivery. While GC therapy improves the ability of the baby to breathe, we have shown that such treatment c

大约10%的孕妇在妊娠晚期接受糖皮质激素（GC）治疗，以促进有早产风险的婴儿的肺成熟。虽然GC治疗可以改善婴儿的呼吸能力，但我们已经证明，这种治疗可以改善婴儿的呼吸能力。