Catalyst study and development in enantioselective transformations and electrode reactions in fuel cells

燃料电池对映选择性转化和电极反应的催化剂研究与开发

• 批准号: 155312-2011
• 负责人: Bergens, Steven
• 金额: $ 5.1万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=522596
• 关键词: Catalyst; study; development; enantioselective; transformations

Our primary objective is to develop efficient, green, and new catalysis to synthesize pharmaceuticals, insecticides, and to produce energy in fuel cells. We maximize the reactivity, lifetime, and reusability of our catalysts by studying how they work, and using this information to guide the preparation of better catalysts and reactions. We prepare active and well-defined dissolved catalysts, insoluble catalysts that have been incorporated into a polymer, and we tailor nanoparticles to act as catalysts in fuel cells. From these studies, we have developed a system that hydrogenates esters to make alcohols under remarkably mild conditions. The industrial version of this reaction requires large amounts of flammable solid hydride reagents that are dangerous to handle and that create waste. Pharmaceuticals are complex molecules. The most efficient way to prepare them is to make simple starting materials complex in the fewest number of steps. For example, we developed a new reaction, the desymmetrization of imides by monohydrogenation. This reaction multiplies the useful molecular complexity that was obtained in one reaction by five. We also construct solid, catalyst-organic frameworks that are the most reusable chiral catalysts to date. We aim to prepare continuous flow reactors and solvent-free reactions with these systems, thereby producing product molecules in a continuous manner without solvent or waste.

我们的主要目标是开发高效、绿色的新型催化剂来合成药物、杀虫剂以及在燃料电池中产生能量。 我们通过研究催化剂的工作原理，最大限度地提高催化剂的反应活性、使用寿命和可重复使用性，并利用这些信息指导更好的催化剂和反应的制备。 我们制备活性和定义明确的溶解催化剂，不溶性催化剂已被纳入聚合物，我们定制纳米粒子作为燃料电池中的催化剂。 从这些研究中，我们已经开发出一个系统，氢化酯，使醇在非常温和的条件下。 这种反应的工业版本需要大量易燃的固体氢化物试剂，这些试剂处理起来很危险，并且会产生废物。 药物是复杂的分子。 制备它们的最有效方法是用最少的步骤将简单的起始材料复杂化。例如，我们开发了一种新的反应，通过单氢化使酰亚胺去对称化。该反应将在一个反应中获得的有用分子复杂性乘以5。我们还构建了固体催化剂有机框架，这是迄今为止最可重复使用的手性催化剂。我们的目标是用这些系统制备连续流动反应器和无溶剂反应，从而以连续方式生产产物分子，而无需溶剂或废物。