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Regulating Rab-mediated membrane trafficking in cell physiology and disease

Regulating Rab-mediated membrane trafficking in cell physiology and disease
调节细胞生理学和疾病中 Rab 介导的膜运输
批准号：
266224
负责人：
McPherson Peter S
金额：
$45.04万
依托单位：
Montreal Neurological Institute-Hospital
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-09-01 至 2017-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=266224&lang=en
关键词：
Denn Domain Endosomes Gef Guanine-Nucleotide Exchange Factor Mental Retardation Neurite Outgrowth Rab Synapse Development Tgn Trans-Golgi Network

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英文摘要
Cells are highly compartmentalized and proteins move between the compartments in small membrane bound transport carriers. This process, called membrane trafficking allows proteins to function at their proper cellular location. Membrane trafficking is hig
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Cell biological basis of a newly identified form of developmental and epileptic encephalopathy caused by variants in DENND5A, a guanine nucleotide exchange factor for Rab GTPases
The growing biomedical significance of intracellular membrane trafficking
Altered membrane trafficking in neurological disease
Endosomal membrane trafficking in cell physiology and cancer
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