Regulation of capillary sprouting and stabilization in skeletal muscle

骨骼肌毛细血管萌芽和稳定的调节

• 批准号: 222865-2013
• 负责人: Haas, Tara
• 金额: $ 2.4万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=523862
• 关键词: Regulation; capillary; sprouting; stabilization; skeletal

The major goal of the research performed in my laboratory is to discover novel strategies for controlling blood vessel formation in skeletal muscle. Growth of new blood vessels is a normal physiological response that enables our muscles to adapt appropriately to varying energy demands. My research group has focused on understanding the processes by which a blood vessel forms a new sprout, which in turn develops into a stable and mature blood vessel, as there is little known about the regulation of these events. The transcription factors, FoxO1 and FoxO3a, are emerging as critical players in the processes of blood vessel formation. This proposal will establish the role of FoxO proteins in regulating the balance between capillary sprouting and stabilization that occurs in skeletal muscle with exercise. My research group will determine whether the FoxO1 and 3 proteins can inhibit sprouting and promote capillary stability. We will define the mechanisms through which the proteins exert these effects. The findings from my research will be novel, and provide a stronger foundation for understanding the normal processes that control blood vessel growth and stabilization. This information could lead to the development of new tools for the manipulation of blood vessel structure.

在我的实验室进行的研究的主要目标是发现控制骨骼肌血管形成的新策略。新血管的生长是一种正常的生理反应，使我们的肌肉能够适当地适应不同的能量需求。我的研究小组专注于了解血管形成新芽的过程，新芽又发展成为稳定和成熟的血管，因为对这些事件的调节知之甚少。 转录因子FoxO1和FoxO3a正在成为血管形成过程中的关键参与者。 该提案将确定FoxO蛋白在调节运动骨骼肌中发生的毛细血管发芽和稳定之间的平衡中的作用。 我的研究小组将确定FoxO1和FoxO3蛋白是否可以抑制发芽并促进毛细血管稳定性。 我们将确定蛋白质发挥这些作用的机制。 我的研究结果将是新颖的，并为理解控制血管生长和稳定的正常过程提供了更坚实的基础。 这些信息可能会导致开发新的工具来操纵血管结构。