Azo polymers for photo-reversible bio-surfaces

用于光可逆生物表面的偶氮聚合物

• 批准号: 227889-2009
• 负责人: Barrett, Christopher
• 金额: $ 5.46万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524138
• 关键词: Azo; polymers; photo; reversible; bio

Cell interactions on surfaces have attracted much recent attention from many materials chemists and physicists, since powerful tools are now available to probe these delicate structures in their native environment at the smallest scales, and many questions can now be framed in chemical terms. Understanding the surface conditions that permit cells to live and function, then permits biomedical engineering advances in regenerative medicine, and tissue repair and replacement. In addition to the chemistry of molecular groups exposed on a surface to a cell, growing cells are also very sensitive to the softness of the surface material, the thickness, the water content, - or + charge, and ion concentrations and gradients. In general, the more 'biological' the artificial surface can be made to appear (wet, soft, charged, warm, and rich in ions and specific functional groups), the more biocompatible it will be with respect to cell adhesion, survival, and function. In order to control the biological interface then, one needs to be able both to measure all of these properties in situ in a true biological environment, and to have the power to manipulate and tune these properties over a wide range with simple preparation protocols.

细胞在表面上的相互作用最近引起了许多材料化学家和物理学家的注意，因为现在有强大的工具可以在最小的尺度上探测这些微妙的结构，并且现在可以用化学术语来定义许多问题。了解允许细胞存活和发挥功能的表面条件，将有助于生物医学工程在再生医学、组织修复和替代方面取得进展。除了暴露在细胞表面的分子群的化学性质外，生长中的细胞还对表面材料的柔软度、厚度、含水量、-或+电荷、离子浓度和梯度非常敏感。一般来说，人造表面的“生物性”越强（湿润、柔软、带电、温暖、富含离子和特定官能团），它在细胞粘附、存活和功能方面的生物相容性就越强。为了控制生物界面，人们需要能够在真实的生物环境中就地测量所有这些特性，并且有能力通过简单的制备方案在大范围内操纵和调整这些特性。