Chemical tailoring of poly(ethylene oxide)-block-poly(ester) copolymers for drug delivery applications

用于药物输送应用的聚（环氧乙烷）-嵌段-聚（酯）共聚物的化学定制

• 批准号: 261196-2013
• 负责人: Lavasanifar, Afsaneh
• 金额: $ 2.11万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525125
• 关键词: Chemical; tailoring; poly; ethylene; oxide

The main purpose of this research is to design and develop novel synthetic materials that can adequately solubilize drugs, release them in an appropriate rate and location, and at the same time, are safe for application in humans. Such compounds are expected to mimic the function of biological transport systems: be recognized as self within the body, carry adequate quantities of the drug to its site of action, release their cargo in the vicinity of their cellular and molecular targets and degrade to biocompatible components afterwards. Synthetic biomaterials are advantageous to their biological counterparts due to the ease of structural modifications, stability and safety of administration.

本研究的主要目的是设计和开发新的合成材料，可以充分溶解药物，以适当的速度和位置释放药物，同时，对人体应用安全。这些化合物有望模拟生物运输系统的功能：在体内被识别为自身，携带足够量的药物至其作用部位，在其细胞和分子靶标附近释放其货物，然后降解为生物相容性组分。合成生物材料由于易于结构修饰、稳定性和给药安全性而优于其生物对应物。