Differential scanning calorimetry for the development of new pharmaceutical with improved performance

差示扫描量热法用于开发性能改进的新药物

• 批准号: 390319-2010
• 负责人: Lavasanifar, Afsaneh
• 金额: $ 5.35万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=443161
• 关键词: Differential; scanning; calorimetry; development; new

Success of many existing drugs or new ones emerging from drug discovery efforts depend on their water solubility, and accessibility to systemic circulation and, more importantly, to the diseased tissue. Our research team is working on the development of new pharmaceutical delivery systems that can enhance the performance of small molecule drugs as well as macromolecular drugs (like peptides, proteins, DNAs and RNAs) by either increasing their water solubility, enhancing their biological stability, providing sustained drug release, increasing their delivery to the diseased tissue or reducing their exposure to sites of drug toxicity. The proposed differential scanning calorimetry instrument is an integral part of this project and is required for this program to succeed. The instrument has different applications in the characterization of these new pharmaceutical drug delivery systems that are expected to make less toxic and more effective drugs for clinical use.

许多现有药物或从药物发现工作中涌现出来的新药的成功取决于它们的水溶性，以及它们对全身循环的可及性，更重要的是，对患病组织的可及性。我们的研究团队正致力于开发新的药物释放系统，通过增加小分子药物和大分子药物(如多肽、蛋白质、DNA和RNA)的水溶性、增强其生物稳定性、提供持续的药物释放、增加其对病变组织的释放或减少其暴露于药物毒性部位，来增强其性能。拟议的差示扫描量热仪是该项目的组成部分，是该项目取得成功所必需的。该仪器在表征这些新的药物给药系统方面有不同的应用，这些系统有望使毒性更低、更有效的药物用于临床。