Differential scanning calorimetry for the development of new pharmaceutical with improved performance

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Success of many existing drugs or new ones emerging from drug discovery efforts depend on their water solubility, and accessibility to systemic circulation and, more importantly, to the diseased tissue. Our research team is working on the development of new pharmaceutical delivery systems that can enhance the performance of small molecule drugs as well as macromolecular drugs (like peptides, proteins, DNAs and RNAs) by either increasing their water solubility, enhancing their biological stability, providing sustained drug release, increasing their delivery to the diseased tissue or reducing their exposure to sites of drug toxicity. The proposed differential scanning calorimetry instrument is an integral part of this project and is required for this program to succeed. The instrument has different applications in the characterization of these new pharmaceutical drug delivery systems that are expected to make less toxic and more effective drugs for clinical use.